Fixed Dose Combination Antimicrobials Practices In Nepal – Review Of Literature
Published: October 1, 2010 | DOI: https://doi.org/10.7860/JCDR/2010/.986
Kadir Alam1,2,3, Arjun Poudel1,4, Subish Palaian 1,2,4
1Department of Hospital and Clinical Pharmacy, Manipal Teaching Hospital, Pokhara, Nepal; 2Department of Pharmacology, Manipal College of Medical Sciences, Pokhara, Nepal; 3Department of Social and Administrative Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University,
Bangkok, Thailand; 4Discipline of Social and Administrative Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.
Correspondence
Kadir Alam
Assistant Professor,
Department of Pharmacology
Manipal College of Medical Sciences
Pokhara, Nepal.
E-mail: alamkad2050@yahoo.com
Phone: 061-526420/526416 (Extn 221)
Antibacterial drugs are one used commonly as fixed dose combination. The use of fixed dose combination antimicrobials is more common in developing countries. There are several studies which suggest extensive use of fixed dose combination antimicrobials drugs in Nepal. Although thousands of fixed dose combination are available in world market, WHO has approved only 25 fixed dose combination in 15th edition of WHO essential drug list. Even if some of the fixed dose antimicrobial offer some benefit in treatment of disease like Tuberculosis, Leprosy etc., majority of irrational fixed dose antimicrobials has major contribution in resistance development, decrease the flexibility of prescriber and increase the misuse by self-medication. To minimize the extensive use of fixed dose combination of antimicrobials certain measure like developing guideline for preparing of combination product, evaluation of product before registration, banning of irrational IFDC antimicrobials, strict monitoring, strict antibiotic policy, hospital antibiotic policy etc., will be helpful. In the developing world where resistance to antimicrobials is increasing, minimizing the use of irrational fixed dose combination antimicrobials can be better tool to combat with the resistance.
[
FULL TEXT ] | [ PDF]